(For a friend)

https://www.invega.com/invega-side-effects-schizoaffective-disorder-treatment.html

https://www.nami.org/About-Mental-Illness/Treatments/Mental-Health-Medications/Types-of-Medication/Paliperidone-(Invega)

https://en.m.wikipedia.org/wiki/Paliperidone

https://en.m.wikipedia.org/wiki/Nanocrystalline_material

https://www.frontiersin.org/articles/10.3389/fbioe.2019.00374/full

https://www.degruyter.com/document/doi/10.1515/nanoph-2020-0489/html

https://en.m.wikipedia.org/wiki/Nanocrystal

https://www.beilstein-journals.org/bjoc/articles/8/39

(Then this)

Here, we demonstrate that the piezoelectric and liquid-crystalline properties of M13 bacteriophage (phage) can be used to generate electrical energy. Using piezoresponse force microscopy, we characterize the structure-dependent piezoelectric properties of the phage at the molecular level. We then show that self-assembled thin films of phage can exhibit piezoelectric strengths of up to 7.8 pm V− 1. We also demonstrate that it is possible to modulate the dipole strength of the phage, hence tuning the piezoelectric response, by genetically engineering the major coat proteins of the phage. Finally, we develop a phage-based piezoelectric generator that produces up to 6 nA of current and 400 mV of potential and use it to operate a liquid-crystal display.

The word piezoelectricity comes from the Greek word piezein, which means squeeze or press and electron, which means “amber” and is an ancient source of electric charge. ... Piezoelectric materials allow conversion of energy from the mechanical domain to the electrical domain and vice versa.

A Wigner crystal is the solid (crystalline) phase of electrons first predicted by Eugene Wigner in 1934.[1][2] A gas of electrons moving in 2D or 3D in a uniform, inert, neutralizing background will crystallize and form a lattice if the electron density is less than a critical value. This is because the potential energy dominates the kinetic energy at low densities, so the detailed spatial arrangement of the electrons becomes important.

To minimize the potential energy, the electrons form a bcc (body-centered cubic) lattice in 3D, a triangular lattice in 2D and an evenly spaced lattice in 1D. Most experimentally observed Wigner clusters exist due to the presence of the external confinement, i.e. external potential trap. As a consequence, deviations from the b.c.c or triangular lattice are observed.[3] A crystalline state of the 2D electron gas can also be realized by applying a sufficiently strong magnetic field. However, it is still not clear whether it is the Wigner-crystallization that has led to observation of insulating behaviour in magnetotransport measurements on 2D electron systems, since other candidates are present, such as Anderson localization.

Magnons, electron spin waves, can be controlled by a magnetic field. Densities from the limit of a dilute gas to a strongly interacting Bose liquid are possible. Magnetic ordering is the analog of superfluidity. The condensate appears as the emission of monochromatic microwaves, which are tunable with the applied magnetic field.

In 1999 condensation was demonstrated in antiferromagnetic TlCuCl3,[16] at temperatures as large as 14 K. The high transition temperature (relative to atomic gases) is due to the small mass (near an electron) and greater density. In 2006, condensation in a ferromagnetic Yttrium-iron-garnet thin film was seen even at room temperature[17][18] with optical pumping. Condensation was reported in gadolinium in 2011.[19] Magnon BECs have been considered as qubits for quantum computing.

Complete answer:

The process of transformation of viral components into organized solid particles is known as crystallization. The inactive form of the virus can be changed into crystals and it includes a large number of viral particles.

Virus-induced oxidative stress plays a critical role in the viral life cycle as well as the pathogenesis of viral diseases. In response to reactive oxygen species (ROS) generation by a virus, a host cell activates an antioxidative defense system for its own protection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131721/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021756/

https://www.sciencedirect.com/science/article/abs/pii/S0149763410001727

https://www.karger.com/Article/Fulltext/314518

schizophrenia susceptibility genes may be found on chromosomes 1, 6, 8, 10, 13 and 22 [see reviews in 9–11]. Very recent studies from large genome-wide scans in multiple, large cohorts that have identified both rare high-risk mutations (RR: 2–14) [12–15] and common low-risk variations on chromosome 2 (ZnF804A) and 11 (RR: 1.09–1.19) [16] and in the HLA and histone regions on chromosome 6 [17]. Similarly, studies that have adopted a family-based approach have identified a balanced translocation that disrupts the DISC1 gene [18], as well as the neuregulin gene [19], while hypothesis-driven approaches based on biological findings of deficits in the ability to cope with oxidative stress in patients with schizophrenia have implicated gene variants in the biosynthesis of glutathione as susceptibility factors of the illness [20, 21].

The findings suggest that higher levels of glutathione — which help regulate levels of glutamate — could help people with schizophrenia or other conditions that cause psychosis respond more quickly to treatment and have better overall outcomes.

Cells produce glutathione as an antioxidant to help resist oxidative stress.

The glutathione-glutamate balance
Glutathione is the most prominent antioxidant found in brain cells. Some studies have found a lack of glutathione in people experiencing psychosis, specifically in the cingulate cortex — a part of the brain associated with emotion regulation, which is highly important in schizophrenia.

Oxidative damage in the brain may contribute in part to the pathological process in BD and schizophrenia. This finding also suggests antioxidative stress as a probable alternative approach to the pharmacological treatment of these psychiatric disorders.