William Makis MD
Most people know Iver as an anti-parasitic medicine, but very few realize that science has uncovered powerful anticancer effects that work on some of the body’s deepest cellular levels.
When studied under the microscope, Ivermctin has been shown to interfere with the very channels and fuel sources cancer depends on to survive.
1. Glutamate-Gated Chloride Channel Activation
Cancer cells maintain electrical and chemical balance through channels in their membranes.
Iver binds to these glutamate-gated chloride channels, forcing an influx of chloride ions that causes the cell to lose control of its voltage balance.
This sudden shift triggers oxidative stress, mitochondrial collapse, and apoptosis (programmed cell death).
In simple terms: it opens the floodgates and short-circuits cancer cells from the inside out.
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2. Starving Cancer’s Fuel Supply
Cancer cells crave glutamine—their main energy source.
Iver helps block glutamine uptake and metabolism, effectively starving tumors while leaving healthy cells unharmed.
This aligns with metabolic therapies that cut off both glucose and glutamine, forcing cancer to burn itself out.
3. Blocking Oncogenic Pathways (PAK1 + WNT/β-Catenin)
Iver has been shown to inhibit PAK1, a protein that promotes tumor growth, and to suppress WNT/β-catenin, which fuels cancer stem-cell renewal.
By quieting these “grow” signals, Iver helps shut down the cancer’s command center.
4. Triggering Apoptosis & Autophagy
Inside the mitochondria, Iver activates caspase pathways that tell damaged cells to self-destruct.
It also promotes autophagy, the body’s natural clean-up process that removes malfunctioning cells—another layer of immune support in the cancer fight.
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5. Reducing Tumor Spread and Inflammation
Iver blocks P2X4 and P2X7 purinergic receptors, which are involved in tumor invasion and inflammatory signaling.
This can reduce metastasis and calm the inflammatory terrain that cancer thrives in.
6. Cutting Off Tumor Blood Supply
Iver helps lower VEGF, the molecule that tells the body to grow new blood vessels for a tumor.
Without that supply line, cancer cells lose their oxygen and nutrients.
Summary of Effects
Mechanism and Actions
Glutamate-gated chloride channels/ Triggers cancer-cell death
Glutamine metabolism blockade/ Starves tumor of energy
PAK1 & WNT/β-Catenin inhibition/ Shuts down growth signals
Mitochondrial apoptosis/ Destroys cancer cells from within
