Goliath was not a nephilim. He was a hybrid. It was up to David & his men to wipe out the giants. However, the bloodline remained. Six fingers, six toes. Many still have this today.
Satan wanted to corrupt Jesus' bloodline. When Jesus would walk through the streets, they said heal us son of David. They recognized God's promise and the precious blood of Jesus. The genealogy.
A spotted lamb was genetically improper for sacrifice. Satan knew that if Jesus' bloodline was improper, the sacrifice for us would be improper. He got beat. This is why the precious blood of Jesus is so important. It's pure. It has POWER.