A service provider for the whole exome data analysis, CD Genomics uses bioinformatics to deeply mine the genetic information in the coding region based on the whole exome sequencing data. Our unique skills in data analysis can meet customers' personalized data analysis needs and provide you with comprehensive data analysis results. https://bioinfo.cd-genomics.com/whole-exome-data-analysis.html

A variant detection and analysis service provider, CD Genomics uses bioinformatics to help you explore the genetic variation and decipher the essence of life. Our unique skills in data analysis can meet customers' personalized data analysis needs and provide you with comprehensive data analysis. https://bioinfo.cd-genomics.com/variant-detection-and-analysis.html

UMI small RNA sequencing (RNA-seq) is a unique molecular identifier (UMI)-based technology for accurate qualitative and quantitative analysis of multiple small RNAs in cells. PCR amplification bias can be removed by adding UMI into each cDNA segment, achieving accurate and unbiased quantification. UMI small RNA-seq can accurately identify SNP, quantify low-abundance transcripts, and reveal comprehensive transcriptome information. We provide UMI small RNA-seq to help you analyze microRNA (miRNA), small interfering RNA (siRNA), piwi-interacting RNA (piRNA) at one time. https://rna.cd-genomics.com/umi-small-rna-seq.html

Total RNA sequencing (RNA-seq) is a next-generation sequencing (NGS)-based method to capture a comprehensive view of the transcriptome. We provide total RNA-seq to help you analyze coding RNAs and multiple forms of ncRNA, including long noncoding RNA (lncRNA), small nuclear (snRNA), small nucleolar (snoRNA), and other ncRNA species. https://rna.cd-genomics.com/total-rna-seq.html

Poly(A) RNA sequencing (RNA-seq) is a next-generation sequencing-based method to comprehensively analyze RNAs with poly(A) tails such as message RNAs (mRNAs) and long non-coding RNAs (lncRNAs). This technique accurately reveals the level of gene expression in your biological sample under specific conditions and generates a complete picture of the transcriptome for the identification of novel alternative splicing, transcripts, gene fusion events, etc. https://rna.cd-genomics.com/polya-rna-seq.html

Our excellent microbial identification platform (including Rep-PCR, MicroSEQ®, NGS-based microbial identification, multi-locus sequence typing, and mycoplasma detection) aims to identify microbial species efficiently and economically in a fast high-throughput, and simple manner. We deliver high-accuracy and high-sensitivity data to help your microbial and laboratory research. https://www.cd-genomics.com/microbioseq/microbial-identification.html

Our Metranscriptomics platform elucidates three aspects of a microbial community, including gene activity diversity, gene expression abundance, and differential gene expression analysis by utilizing the most advanced next and third generation sequencing technologies and integrated bioinformatics analysis. The gene expression analysis can tell which genes exhibit the highest change in expression levels in different conditions to identify potential biomarkers and expression signatures. https://www.cd-genomics.com/microbioseq/metatranscriptomics.html

Our microbial diversity analysis platform based on 16S/18S/ITS amplicon sequencing aims to characterize microbial diversity efficiently and economically by utilizing the next/third generation sequencing technology and other molecular technologies. Our scientists utilize this platform to assist our customers for meeting both scientific and regulatory requirements. https://www.cd-genomics.com/microbioseq/microbial-diversity-analysis.html

CD Genomics is committed to providing novel NGS services enabling researchers to explore structure and function of the microbial community in a high-resolution and culture-independent manner using technology from Illumina and PacBio. In addition, we also offer the service to sequence the genome of the individual cultured bacteria, fungi, phage or virus, whether do novo or re-sequencing. https://www.cd-genomics.com/microbial-genomics.html

CD Genomics offers the transcriptome-wide analysis of the location of m6A in mRNA transcripts and other RNAs by methylated RNA immunoprecipitation sequencing (MeRIP-seq). MeRIP-seq uses an antibody that specifically detects and characterizes of N6-methyladenosine (m6A) in RNA. As 3'UTR of mRNA plays important role in mRNA stability, localization, and translation, and may affect the binding of RNA-regulatory proteins to these regions, enrichment of m6A in this region indicates that m6A may affect RNA metabolism and gene expression. Inhibition of the enzymes that involve in the RNA methylation has also provided clues to the potential biological roles of this modification. Hence, the identification and characterization of modified bases in RNA may lead to a better understanding of biological pathways. https://www.cd-genomics.com/merip-sequencing.html

ChIP-Seq (chromatin immunoprecipitation sequencing), which refers to the binding site analysis, is a way to analyze DNA-protein interactions. The technique combines chromatin immunoprecipitation (ChIP) with NGS to identify where the DNA binds to the associated proteins. It can be used to pinpoint the binding sites of any interested protein throughout the genome. ChIP-seq is often used to determine how transcription factors and other chromatin-related proteins affect phenotypic mechanisms. https://www.cd-genomics.com/chip-seq.html

CD Genomics provides bacterial de novo sequencing data analysis. Using bioinformatics to explore the whole genome sequence map of bacteria in one step, our unique data analysis skills and advanced software tools can meet our customers' personalized data analysis needs and provide you with easy-to-interpret data analysis reports. https://bioinfo.cd-genomics.com/bacterial-de-novo-sequencing-analysis.html

As one of the group evolution analysis providers, CD Genomics uses bioinformatics to help you analyze the population information and reveal the process of population evolution quickly and accurately. Our unique data analysis skills can meet customers' personalized data analysis needs and provide the most easy-to-interpret data analysis reports. https://bioinfo.cd-genomics.com/group-evolution-analysis.html

CD Genomics provides a battery of biofluid profiling services utilizing next-generation sequencing technology. Our services can complement mainstream sequencing methods to investigate the levels of RNA molecules in biofluid samples, explore poorly characterized, rare transcripts and mutations. Cell-free RNA sequencing (RNA-seq) is a tool that extracts, processes, and analyzes cell-free RNA. We have developed a complete, automated workflow for performing cell-free RNA-seq. Our services are fully customizable to your research needs. https://rna.cd-genomics.com/cell-free-rna-seq.html

Next-generation sequencing (NGS)-based methods, either relying on antibody enrichment or third-generation sequencing, have been developed to map post-transcriptional RNA modification and explore their functions, We provide a full range of epitranscriptomics services to investigate RNA modifications using NGS or long-read sequencing (Oxford nanopore sequencing and PacBio SMRT sequencing). We can help you detect many forms of RNA modifications including m7G, m3C, m1A, 5mC, 5hmC, m6A, m6Am, acetylation, and 2'-O-methylation. https://rna.cd-genomics.com/epitranscriptomics.html

Viral metagenomic studies have provided insights into viral ecology by elucidating the genetic potential, community structure, and biogeography of environmental viruses. Viral metagenomics has expanded current knowledge on virus-host interactions by uncovering genes that may allow the viruses to manipulate their hosts in unexpected ways. The intrinsic potential for virus discovery through viral metagenomics can help advance a wide array of disciplines including evolutionary biology, pathogen surveillance, and biotechnology. In addition, functional viral metagenomics serves as a platform to discover more useful enzymes. As the annotation of viral genes continues to improve, the discovery of vital enzymes will increase considerably. https://www.cd-genomics.com/microbioseq/viral-metagenomics.html

Fungi, a large group of eukaryotes, consist of microorganisms such as yeast and mold, as well as the mushrooms. Many beneficial fungi have important nutritional and medicinal value. However, some pathogenic fungi can cause disease in humans, animals, or plants. With the maturity of high-throughput sequencing technologies, the cost of genome sequencing has been greatly reduced, making it possible to sequence fungal genomes quickly and economically. Fungal whole genome sequencing allows us to obtain the genome sequence of fungi and study their structure and function. https://www.cd-genomics.com/microbioseq/fungal-whole-genome-sequencing.html

Long-read sequencing technologies, including PacBio SMRT and Oxford Nanopore sequencing, make it possible to detect variants in genomic regions that are proposed difficult to map through typical short-read sequencing methods (such as Illumina sequencing). CD Genomics is a leading global life sciences company. We specialize in the application of third-generation sequencing technologies. With the help of our advanced platform and skilled experts, researchers can detect all variant types from long-read datasets and discover new variants in complex genomic regions. https://longseq.cd-genomics.com/variant-calling.html

CD Genomics is a leading provider of genomic services. We have extensive experience in long-read amplicon sequencing using the PacBio platform. PacBio SMRT long-read sequencing is capable of generating complete, uniform, unbiased coverage spanning long amplicons, allowing for a more realistic restoration of the microbial community structure in the samples. 16S/18S/ITS amplicon sequencing, also known as microbial diversity sequencing, refers to the sequencing of PCR products from specific regions such as 16S ribosomal DNA (rDNA), 18S rDNA, Internal Transcribed Spacer (ITS), and functional genes. This method does not require culturing microorganisms, and by detecting sequence variation and abundance in the target region, information on microbial community structure, evolutionary relationships, and microbial relevance to the environment can be obtained from environmental samples. https://www.cd-genomics.com/longseq/full-length-16s-18s-its-amplicon-sequencing.html

The identification of microorganisms has relied on phenotypic methods at early eras. With advances in genetic methods, various classification methodologies based on nucleotide sequences are increasingly popular due to their specificity and speed. Gene sequencing-based techniques can serve to detect, identify, and monitor microbes, even poorly known or uncultured microorganisms. https://www.cd-genomics.com/microbial-identification-1.html

CD Genomics is proud to provide genotyping by sequencing service to advance your population based genotyping studies in an effective and economic way. Please contact us for more information and a detailed quote. CD Genomics is the licensed service provider for this technology. Keygene N.V. owns patents and patent applications protecting its Sequence Based Genotyping technologies. https://www.cd-genomics.com/genotyping-by-sequencing-gbs.html

A series of studies have confirmed that T-cell receptor (TCR) repertoire could sever as a biomarker for monitoring immune response. CD Genomics has developed a state-of-the-art high throughput sequencing method (TCR-Seq) to characterize the TCR repertoires. TCR, which locates on the surface of T cells, is responsible for the recognition of the Ag-MHC (major histocompatibility complex) molecules. The recombination of the variable (V), diversity (D), and joining (J) genes generates the immense diversity of TCR, which is critical to the adaptive immune system. In this way, the sequencing and analysis of TCR repertoire may help to obtain a better understanding of the response of adaptive immunity, and ultimately, sheds light on the discovery of novel infectious agents and holds the invaluable potential to aid in antibody or vaccine development, clinical diagnosis, treatment, and prevention. https://www.cd-genomics.com/tcr-seq.html

Genotyping helps determine differences in the individual's genetic makeup, such as single nucleotide polymorphisms (SNPs) and large structural changes in DNA. Genotyping analysis plays an important role in research of genes and gene variants associated with disease. Next-generation sequencing (NGS) and microarrays enable a deeper understanding of disease etiology on a molecular level. With multiple genomic targets potentially contributing to disease, analysis requires flexibility and accuracy. SNP genotyping and copy number variation (CNV) data analysis tools can analyze results for millions of markers and probes and detect sample outliers, providing insight into the functional consequences of genetic variation. SNP genotyping is also used in many scientific disciplines including personalized medicine, plant and animal biotechnology. https://bioinfo.cd-genomics.com/genotyping-analysis.html

In genetics, a genome-wide association study (GWAS) is an observational study of a genome-wide set of genetic variants in different individuals to investigate whether any variant is associated with a trait. GWASs typically focus on associations between single-nucleotide polymorphisms (SNPs) and traits like major human diseases, but can equally be applied to any other genetic variants and any other organisms. As one of the providers of genome-wide association analysis, CD Genomics uses bioinformatics to help you achieve efficient mapping of multiple target trait genes quickly and accurately. Our unique data analysis skills can meet customers' personalized data analysis needs and provide easy-to-interpret data analysis reports. https://bioinfo.cd-genomics.com/genome-wide-association-analysis.html

CD Genomics not only provides comprehensive short-read and long-read sequencing services, but also has a professional bioinformatics team to guide the analysis solutions of genomic, transcriptomic and epigenomic metadata. We provide session analysis services not limited to sequencing data quality control, annotation, alternative splicing analysis, assessment, differential expression analysis, regulatory interaction network, and functional analysis. We are experienced in helping to analyze abiotic and biotic stress, developmental stages, therapeutic and other bioinformatics analysis and genome data mining. We deliver the complete report of methods, tools, visualization analysis results and all other reports in a secure and confidential service process. https://rna.cd-genomics.com/rna-bioinformatics.html

MicroRNAs (miRNAs) are key regulators of gene expression and their dysregulation has been associated with various diseases. Understanding the interactions between miRNAs and messenger RNAs (mRNAs) is crucial for unraveling gene regulatory networks and discovering diagnostic and prognostic markers. CD Genomics offers a comprehensive miRNA-mRNA interaction analysis service to investigate these relationships using deep sequencing and advanced bioinformatics techniques. https://rna.cd-genomics.com/mirna-mrna-interactions-analysis.html

Tag-Seq is a high-throughput sequencing approach that is primarily used for characterizing gene expression levels and identifying novel transcripts. The data generated by the service can be useful for a wide range of applications, including gene expression studies, biomarker discovery, and transcriptome annotation. https://rna.cd-genomics.com/tag-seq.html

DNA methylation also contributes to cellular differentiation and development of organisms, which is crucial to understand gene expression and silencing in the development of cancer and other diseases. Microbial epigenomics provides insight into important tumorigenic pathways and enables us to find the molecular markers in multiple biological processes and understand underlying mechanisms associated with complex diseases. Microbial epigenomics analysis can be used in many areas of research, including cell cycle control, DNA repair, developmental biology, cancer research, and discovery of potential biomarkers and drug targets. https://www.cd-genomics.com/microbioseq/microbial-epigenomics.html

Multi-locus sequence typing (MLST) is a molecular biology method with high resolution based on the analysis of internal fragments of multiple housekeeping genes by PCR and sequencing. It can be used to identify and classify unidentified bacterial and fungal organisms at the species and strain levels. It has been applied in both molecular epidemiological studies and molecular evolution analysis. We provide MLST service to help you characterize isolates of microbial species and to accelerate studies of SNPs, resistance genes, and virulence factors of strains. https://www.cd-genomics.com/microbioseq/multi-locus-sequence-typing.html

CD Genomics' single molecule, real-time sequencing (SMRT)-based microbial targeted and whole-genome sequencing services can help you with precise microbial identification, generation of complete reference genomes, comparative genomic studies, and genomic exploitation. The applications for SMRT-based genome sequencing vary. Just to list a few: accurate microbial identification, microbial genomic characterization, pathogen detection, environmental monitoring, and routine testing of raw materials for bacterial contamination. https://www.cd-genomics.com/microbioseq/smrt-based-genome-sequencing.html