Pelargonidin is a natural plant pigment belonging to the group of compounds known as anthocyanins. It is responsible for the red, orange, or pink coloration observed in various fruits, flowers, and vegetables. Pelargonidin is widely distributed in nature and is particularly abundant in berries such as strawberries, raspberries, and cranberries. https://metabolomics.creative-proteomics.com/pelargonidin-analysis-service.htm

"What is butanoic acid?
Propanoate metabolism depicts the metabolism of propionic acid. Propionic acid basically stems from the production of the acid by either gut or skin microflora. Propanoate is converted into propanol adenylate via propionyl-CoA synthetase and acetyl-CoA synthetase in mitochondrial. The propionyl adenylate then is converted into propionyl coenzyme A (propionyl-CoA), which is carboxylated into D-methylmalonyl-CoA via propionyl-CoA carboxylase. " https://metabolomics.creative-proteomics.com/propanoate-metabolism-service.htm

In IEF, proteins migrate to their respective pI and remain stabilized. To conduct successful IEF, stable and linear pH gradients are important. Creative Proteomics provides a high-resolution IEF capable of separating proteins with different pI point. Depending on your samples, different antibodies, antigens, and enzymes will be employed to ensure the successful fractionation. Buffers and ampholyte conditions will also be optimized to separate proteins across a broad range of pH. https://www.creative-proteomics.com/pronalyse/pi-determination-with-ief.html

PEGylation is a process of attaching one or more molecules of polyethylene glycol (PEG) to target biomolecules including peptides, proteins and oligonucleotide. It is a vital modification used in biopharmaceuticals to facilitate the functions of therapeutic proteins and peptides. PEGylation of proteins improves pharmacokinetic and pharmacodynamic properties of proteins. PEG has been approved as pharmaceutical excipient for injection by FDA. https://www.creative-proteomics.com/pronalyse/pegylated-protein-analysis-service.html

Water-soluble vitamins (WSVs), encompassing the B-complex vitamins and vitamin C, represent a category of organic compounds essential for sustaining human life. They actively participate in the regulation of physiological processes within the body and serve as crucial bioactive substances for maintaining human health. Our company offers a single injection quantitative determination of multiple water-soluble vitamins. This vitamins water soluble method provides strong specificity, high sensitivity, and reliable stability. https://www.creative-proteomics.com/services/water-soluble-vitamins-analysis-service.htm

The tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or the Krebs cycle, is a crucial metabolic pathway in all aerobic organisms. And the TCA cycle plays a pivotal role in I) Energy production: the catabolism of carbohydrates, lipids, and proteins for ATP production. II) Intermediary metabolism: in addition to producing energy, the TCA cycle also serves as a central hub for the interconversion of metabolic intermediates. With over a decade of experience in metabolomics services, Creative Proteomics can provide superior service for analyzing TCA cycle metabolites. https://www.creative-proteomics.com/services/tca-cycle-analysis-service.htm

Tandem affinity purification (TAP) is a rapid technique used to study protein-protein interactions in vivo. Through two steps of specific affinity purification, TAP allows for the rapid isolation of proteins that interact with the target protein under physiological conditions. Originally developed for use in yeast, the TAP method has rapidly evolved due to its versatility, efficiency, high purity, and low false positives. It has since been successfully applied to the study of protein interactions in various other organisms, including mammals and plants. https://www.creative-proteomics.com/services/tandem-affinity-purification-tap-ms-service.htm

The combination of MS instrument and liquid chromatography (LC) can effectively separate target lipid molecules from complex samples. High-quality and accurate lipid level analysis helps to study the changes in the content of CDP-DAG under physiological and other pathological conditions, and accelerate the analysis of biomarkers and related disease mechanisms. https://lipidomics.creative-proteomics.com/cdp-diacylglycerols.htm

Sulfatide (ST) is an acid glycosphingolipid, which is widely present in various tissues, organs and blood components of the human body. ST is a multifunctional molecule that plays an important role in multiple systems and plays an important pathophysiological role in the pathogenesis of different diseases, including nervous system, cardiovascular system, autoimmune system, tumor and infection, etc.. Creative Proteomics provides LC-MS/MS technology platform to provide you with sulfatide assay services, aiming to accelerate related basic research and clinical prevention and treatment of various related diseases. https://lipidomics.creative-proteomics.com/sulfatides-targeted-lipidomics.htm

Our professional platform can provide cardiovascular biomarker analysis of inflammation and oxidative stress to accelerate the identification/prediction of relevant mechanisms of the occurrence and development of CVD, and promote the development of targeted therapeutic drugs. The samples we can detect are not limited to human samples, but also include other species. https://cytokine.creative-proteomics.com/cardiovascular-disease-biomarker-assay.htm

Redness, hot pain as well as sepsis, are symptoms of the pathological process of infectious inflammation, a phenomenon that occurs with the participation of mediators produced by a large number of inflammatory cells, where cytokines are also involved. Cytokines are biologically active low molecular weight proteins or peptides secreted by various cells that regulate cell growth and differentiation, immune function, inflammation and wound healing. When pathogens invade or the body ages, inflammation cytokine signalling activate the body's immune system to defend against invaders. And when invaders are eliminated and the body needs to regain stability, anti-inflammatory cytokines are secreted. The constant interaction and balance between inflammatory and anti-inflammatory cytokines is an important part of the human immune system. https://cytokine.creative-proteomics.com/cytokines-in-inflammation.htm

The carbohydrate metabolism provides a versatile tool to assess medical risks, identify novel biomarkers and gain insight to molecular mechanisms of disease by analysing hundreds of carbohydrate metabolites in individual’s samples. The carbohydrate metabolism analysis has been applied in a wide range of fields including biomarker discovery, human disease research, clinical diagnostics, drug discovery, food safety, nutrition and systems biology. With integrated array of separation, characterization, identification and quantification experience, Creative Proteomics provides reliable, rapid and cost-effective analysis of carbohydrates services for your various scientific purposes. https://metabolomics.creative-proteomics.com/carbohydrate-metabolism-analysis.htm

What are carotenoids? Carotenoids, a diverse group of pigments found in various organisms, exhibit a remarkable array of colors ranging from vibrant reds and oranges to bright yellows. These visually appealing compounds have captured the attention of scientists and researchers for their intriguing properties and multifaceted roles. In addition to their visual impact, carotenoids also possess significant nutritional and health benefits, making them a subject of extensive analysis and study. https://metabolomics.creative-proteomics.com/carotenoids-analysis-service.htm

Creative Proteomics offers a comprehensive protein intact mass analysis service using advanced mass spectrometry techniques to ensure the safety and efficacy of biopharmaceuticals. Our state-of-the-art mass spectrometry instruments and experienced scientists can accurately determine the molecular weight of intact proteins to help identify impurities, modifications, and structural changes. https://www.creative-proteomics.com/pronalyse/protein-intact-mass-analysis-service.html

Protein molecules are biological macromolecules formed by many amino acids connected by peptide bonds. Physiologically functional proteins in the body are all ordered structures. Each protein has a certain percentage of amino acid mass, the sequence of amino acids, and the specific arrangement position of the peptide chain space. Therefore, the protein molecular structure composed of the sequence of amino acids and the spatial arrangement of peptide chains is the structural basis for each protein to have a unique physiological function. https://www.creative-proteomics.com/pronalyse/protein-primary-structure-characterization-methods.html

Sample preparation and extraction of steroids is by either liquid-liquid extraction (LLE) or supported liquid extraction (SLE) followed by an on-line 2D polishing extraction. Target steroid analytes are chromatographically separated on a reverse-phase (RP) column. All analytes and Internal Standards are measured by ESI ionization--pos and/or neg polarity (analyte dependent). Creative Proteomics provide customer-tailored service with rapid peptide steroids analysis procedures and easy to read report, to speed up your scientific research. https://www.creative-proteomics.com/services/steroids-analysis-service.htm

Protein Sequence Analysis is the process of subjecting a protein or peptide sequence to one of a wide range of analytical methods to study its features, function, structure, or evolution. Methodologies used include sequence alignment, searches against biological databases, and other methods. Since the development of methods of high-throughput production of protein sequences, the rate of addition of new sequences to the databases increased exponentially. https://www.creative-proteomics.com/services/protein-sequence-analysis-service.htm

"What is a phytohormone?
Plant hormones, also known as phytohormones, are endogenously synthesized compounds in plants. They play crucial roles in regulating responses to external environmental changes, modulating growth states, resisting adverse conditions, and maintaining essential metabolic processes. Phytohormones are of significant importance in plant growth and development, pest and disease resistance, breeding, and protection. Consequently, there is an increasing interest in metabolomics techniques specifically designed for the targeted quantification of plant hormones." https://www.creative-proteomics.com/services/plant-hormone-analysis-service.htm

Lipids are hydrophobic or amphipathic small molecules which include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides and phospholipids. The important roles of lipids in biological physiology are evident not only in energy storage and structural components of cellular membranes, but also in signal transduction, membrane trafficking and morphogenesis. lipid content analysis is the synthesis and degradation of lipids in cells, consisting of the breakdown or storage of fats for energy and the synthesis of structural and functional lipids like those involved in the construction of cell membranes. https://metabolomics.creative-proteomics.com/lipid-metabolism-service.htm

Inositol phosphates contain multiple phosphorylated derivatives and individual PIPs can contain different fatty acid chains, resulting in structural complexity. Creative Proteomics has built a dedicated analytical platform to provide you with qualitative and quantitative analysis of inositol phosphates. Based on ion chromatography separation techniques, we are able to accurately determine the total amount of phosphorylated derivatives. Based on LC/MS technology, we are able to quantify inositol phosphate pathway containing specific fatty acid chain structures. https://metabolomics.creative-proteomics.com/inositol-phosphates-metabolism-service.htm

Starch is a polymeric carbohydrate consisting of a large number of glucose units connected by glycosidic bonds. Similarly, sucrose is a kind of carbohydrate and composed of two monosaccharides: glucose and fructose. Basically, the starch and sucrose metabolism begin with D-fructose that interacts with a D-glucose in a reversible reaction through a maltodextrin glucosidase. By multiple procedures, the metabolism of starch and sucrose produce several important intermediates like glucose-6-phosphate and fructose-6-phosphate, which interact with other metabolic pathways including glycolysis and gluconeogenesis. Creative Proteomics has advanced mass spectrometry instrumentation and a team of bioinformatic analysts to provide starch analysis method. https://metabolomics.creative-proteomics.com/starch-and-sucrose-metabolism-service.htm

Apoptosis plays an important role in the immune system, which is closely related to intracellular homeostasis, T cell aggregation, death of reactive lymphocytes and cytotoxic response of target cells. At present, it has been found that eukaryotic cell apoptosis mainly has the following pathways: 1. Cell receptor-mediated external apoptotic pathways; 2. Internal mitochondrial pathway; 3. B-granase mediated apoptosis pathway; 4. Endoplasmic reticulum stress pathway mediates apoptosis. The detection of cytokines related to apoptosis helps to study apoptosis and the physiological or pathological processes involved. Creative Proteomics can simultaneously quantitatively detect apoptosis and proinflammatory cytokines through a variety of technologies, and provide higher sensitivity and a wider detection range. https://cytokine.creative-proteomics.com/apoptosis-cytokines-assay.htm

Inflammatory cytokines can regulate the response of pro-inflammatory cytokine production, mainly including IL-4, IL-5, IL-10, IL-13, transforming growth factor (TGF), epiodermal growth factor and so on. Among them, IL-4 can inhibit the production of other pro-inflammatory cytokines such as IL-1 and IL-6, as well as the production of lymphocytes and macrophages. IL-10 can inhibit the production of activated monocytes, macrophages, granulocytes and T cells. And IL-13 can inhibit the production of pro-inflammatory transmitters and down-regulate the function of monocytes with cytotoxicity. TGF-β can inhibit the inflammatory response of intestine. And EGF can stimulate tissue repair and protect the mucosa of gastrointestinal tract. Creative Proteomics can provide cytokine detection platform for brain inflammation cytokine research. https://cytokine.creative-proteomics.com/cytokines-in-inflammation.htm

Serum and plasma samples provide a holistic view of systemic responses. These liquid components of blood circulate throughout the entire body, offering a comprehensive representation of the intricate cytokine networks at play. This approach ensures that the analysis captures the full spectrum of cellular communication, enabling a more nuanced understanding of physiological processes. Creative Proteomics can provide you with a one-stop serum cytokine analysis for cytokine and protein detection and quantification. https://cytokine.creative-proteomics.com/serum-plasma-cytokine-assay.htm

Lipid modifications include Glycosyl-phosphatidylinositol anchor (GPI). At the C-terminus of proteins, it happens in the endoplasmic reticulum that the post-translational linkage between glycosylphosphatidylinositol and the modified proteins are translocated to the membrane, which are remain anchored to the outer leaflet of the cell membrane. Methods for detecting protein lipidation have been exploited to predict GPI-anchored proteins, N-myristoylated, S-isoprenylated or S-palmitoylated proteins, and so on. The traditional approaches are based on the incorporation of radioactive precursors and subsequent detection of the proteins by fluorography. Mass spectrometry (MS) methods are universally applied, which are for the mapping of post-translational modifications. This technology submits crucial advantages. Bio-orthogonal probes, reactions compatible with biomolecules that allow their study in their native settings. https://www.creative-proteomics.com/pronalyse/lipidation-analysis.html

Our protein C-terminal sequencing technology service can provide C-terminal sequencing analysis methods for biopharmaceutical proteins or other biological reagents such as MALDI-ISD for Top-down protein C-terminal sequencing and carboxypeptidase hydrolysis. Creative Proteomics is a reliable biopharmaceutical partner with professional proteomics research resources. We use first-class experimental platform and mature technical methods to provide you with high-quality one-stop service. https://www.creative-proteomics.com/pronalyse/c-terminal-sequencing-analysis-service.html

Circular dichroism (CD) spectroscopy is a fast, simple, and accurate method for studying protein structures in dilute solutions. The structural analysis was performed using the circular dichroism of proteins and the difference in absorption of left and right circularly polarized light by asymmetric molecules. As a reliable partner of biopharmaceutical companies, Creative Proteomics can provide customers with far UV circular dichroism spectroscopy analysis services based on GLP / GMP. The detectable molecules range from small chiral drugs and transition metal complexes to biological macromolecular structures such as proteins, glycoproteins and nucleic acids. https://www.creative-proteomics.com/pronalyse/circular-dichroism-spectroscopy-far-uv.html

LC-MS/MS platform enable simultaneous relative and absolute quantification of multiple metabolites in a biological system. The results are widely used for biomarker discovery by investigating the relative changes in metabolite concentrations. The resulting data have been widely used to for biomarker discovery. By providing the exact molecular weights and retention time, LC-MS/MS techniques serves as a powerful analytical tool for identification and quantification of small molecules (metabolites). Creative Proteomics has established sensitive, reliable, and accurate HPLC-MS/MS method for quantification of metabolites in pentose phosphate pathway metabolites. https://www.creative-proteomics.com/services/pentose-phosphate-pathway-analysis-service.htm

Lignin is one of the most abundant aromatic biopolymer in nature and accounts for nearly 30% of the plants. Its deposition in the cell wall plays vital roles for plant development, such as providing rigidity and strength to the cell wall to give structural support for the plant cell wall. Lignin exhibits hydrophobicity in favor of the transport of water and solutes in the vascular system. It also protects the cell against pathogens. As one of the leading companies in the omics field with over years of experience in omics study, Creative Proteomics provides glycomics analysis service customized to your needs. https://www.creative-proteomics.com/services/lignin-content-analysis.htm

Glycolysis pathway is a common metabolic pathway in both prokaryotic and eukaryotic cells. It takes place in the cytosol in eukaryotic cells. By converting glucose into two molecule of the three‐carbon compound pyruvate and generating two ATPs, glycolysis pathway generates the ATP needed for energy‐requiring processes and the pyruvate needed for the complete oxidation of glucose to carbon dioxide and water. With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective glycolysis pathway metabolites targeted metabolomics services. https://www.creative-proteomics.com/services/glycolysis-pathway-analysis-service.htm