... and here you have HCQ - also on nih.gov

"We do not believe that randomized controlled studies are necessary before HCQ is authorized for general use because the efficacy seen in studies already performed indicates that control patients in such studies might die unnecessarily, and because the time delay to perform any such study would cause yet more deaths by preventing HCQ use when it is most needed: immediately! Our study has shown that good evidence of efficacy exists and that there is no safety, cost or supply reason to not treat now. Unnecessary death from delayed treatment is too high a price to pay for greater certainty of knowledge. Many may have already died unnecessarily as a result of inaccurate HCQ information. It is imperative that we do not further add to the COVID-19 death toll by refusing to prescribe HCQ."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534595/