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A blood clot med called Pra.... made by BI was recently approved for use in children 3 months - just under 12 years, the FDA was happy to announce.
Why are children at risk for blood clots now?
F indeed.
First, we assessed bimodal connectivity of structurally altered candidate regions using meta-analytic connectivity modeling (MACM) and resting-state correlations employing openly accessible data. We compared the ensuing connectivity maps to the activation likelihood estimation (ALE) maps of a recent quantitative meta-analysis of brain activity during processing of sexual stimuli. Second, we functionally characterized the structurally altered regions employing meta-data of a large-scale neuroimaging database. Candidate regions were functionally connected to key areas for processing of sexual stimuli.
Moreover, we found that the functional role of structurally altered brain regions in pedophilia relates to nonsexual emotional as well as neurocognitive and executive functions, previously reported to be impaired in pedophiles. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The findings moreover indicate that structural alterations account for common affective and neurocognitive impairments in pedophilia. The present multi-modal integration of brain structure and function analyses links sexual and nonsexual psychopathology in pedophilia.
The sudden and uncontrollable paedophilia exhibited by a 40-year-old man was caused by an egg-sized brain tumour, his doctors have told a scientific conference. And once the tumour had been removed, his sex-obsession disappeared.
The cancer was located in the right lobe of the orbifrontal cortex, which is known to be tied to judgment, impulse control and social behaviour. But neurologists Russell Swerdlow and Jeffrey Burns, of the University of Virginia at Charlottesville, believe it is the first reported case linking damage to the region with paedophilia.
“We’re dealing with the neurology of morality here,” says Swerdlow. Since the area does not affect physical health, “it’s one of those areas where you could have a lot of damage and a doctor would never suspect something’s wrong,” he says.
“He wasn’t faking,” says Burns. “But if someone argues that every paedophile needs a MRI, the difference in this case was that the patient had a normal history before he acquired the problem. Most paedophiles develop problems early on in life.”
