Depletion of the bone structure is the consequence of a self worth conflict in the respective part of the body.
After the conflict is solved, the bone structure is being recalcified while the periosteum is stretched due to the swelling in which the regeneration takes place. This causes pain, but also tells us to keep calm while the body is healing itself.
The problem is that people who don't understand this regulation process, will take the healing pain as "something is wrong" and suffer a new self worth conflict, starting the biological program over and over, ending up in a downwards spiral and getting a chronical arthrosis diagnosis label from conventional medicine.
Substances can alleviate the regeneration / healing phase, but only the body can heal itself.