I use it all the time. Once, I had an infection in my tooth around the gums, and I placed a drop of oregano oil on it; it disappeared overnight. I know you're not supposed to put it on an open wound, but I also used it on a spider bite on my knee that was getting ugly. When I put it on, it made this sizzling sound. I put it on two more times. It was reduced to a little red mark and then disappeared. I am taking it now in my coffee because allergies have caused some sinus stuff.