B cells are classified into two types: B-1 cells and B-2 cells, based on their distinct origins and roles. Approximately 45% of B lymphocytes in peripheral blood are B-2 cells, which are classical B lymphocytes found mostly in lymphoid organs and peripheral blood. Following their initial interaction with an antigen, B-2 cells go through clonal growth and generate high-affinity IgM antibodies with T cells' assistance.

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